Compound-specific Na+channel pore conformational changes induced by local anaesthetics
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منابع مشابه
Conformational Changes in the Pore of CLC-0
The Torpedo Cl- channel, CLC-0, is inhibited by clofibric acid derivatives from the intracellular side. We used the slow gate-deficient mutant CLC-0C212S to investigate the mechanism of block by the clofibric acid-derivative p-chlorophenoxy-acetic acid (CPA). CPA blocks open channels with low affinity (KDO= 45 mM at 0 mV) and shows fast dissociation (koff = 490 s-1 at -140 mV). In contrast, the...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2005
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2004.081646